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- Title
H-ras-1 restriction fragment length polymorphism in normal individuals and oral cancer patients in India.
- Authors
Bhoite, Leena T.; Saranath, Dhananjaya; Nair, Rama; Deo, Madhav G.; Sanghavi, Vikram; Mehta, Ashok; Bhoite, L T; Saranath, D; Nair, R; Deo, M G; Sanghavi, V; Mehta, A
- Abstract
Restriction fragment length polymorphism (RFLP) of the human H-ras-1 gene has been indicated as a marker for detection of individuals at high risk of cancer. We have investigated the association of RFLP at the H-ras-1 locus and susceptibility to oral cancer by Southern hybridization analysis in 77 primary oral tumors and 99 healthy donors. The frequency distribution of the BamHI fragments of H-ras-1 revealed homozygous or heterozygous alleles in the two subpopulations. The heterozygous genotype occurred more frequently in the normal subjects (53%) as compared to the cancer patients (36%). Four common alleles-C1 to C4, were noted predominantly in both groups, with rare alleles detected at a lower frequency. The common allele with 7.6 kb BamHI fragment was significantly higher in normals (10%) than in the tumor population (4%) (P < 0.05). However, a similar distribution of rare alleles in both groups indicated that the presence of rare alleles is not indicative of predisposition to oral cancer.
- Subjects
INDIA; ORAL cancer; GENETIC polymorphisms
- Publication
Journal of Oral Pathology & Medicine, 1993, Vol 22, Issue 7, p298
- ISSN
0904-2512
- Publication type
journal article
- DOI
10.1111/j.1600-0714.1993.tb01076.x