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- Title
The effect of cortical spreading depression on cerebral blood flow and apoptosis in rats after subarachnoid hemorrhage.
- Authors
HAO Pu-heng; SONG Jin-ning; CHEN Hu; AN Ji-yang; YAN Wen-tao; LI Yu; WANG Jun-feng; ZHANG Ming
- Abstract
Objective To clarify the effect of cortical spreading depression (CSD) on cortical cerebral blood flow and apoptosis following subarachnoid hemorrhage (SAH) in rats. Methods SAH was induced in male Wistar rats by autologous blood injection into the cisterna magna and CSD was induced in rats with KCl. The cortical blood flow was measured by laser Doppler flowmeter and apoptosis were detected by TUNEL staining. Results In SAH groups the cortical cerebral blood flow was significantly reduced and cortical cell apoptosis was increased compared with those in blank and normal saline groups. After CSD, the cortical cerebral blood flow and apoptosis in SAH groups were more obvious than in blank and normal saline groups. Conclusion CSD can reduce cortical cerebral blood flow and aggravate apoptosis after SAH. It may be one of the mechanisms of delayed ischemic neurologic deficit.
- Subjects
CEREBRAL circulation; APOPTOSIS; SUBARACHNOID hemorrhage; LABORATORY rats; MENTAL depression; ISCHEMIA
- Publication
Journal of Xi'an Jiaotong University (Medical Sciences), 2013, Vol 34, Issue 6, p754
- ISSN
1671-8259
- Publication type
Article
- DOI
10.7652/jdyxb201306011