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- Title
IL-9 Contributes to Immunosuppression Mediated by Regulatory T Cells and Mast Cells in B-Cell Non-Hodgkin's Lymphoma.
- Authors
Feng, Li-Li; Gao, Jun-Ming; Li, Pei-Pei; Wang, Xin
- Abstract
It has been known that regulatory T (Treg) cells and mast cells (MCs) are involved in tumor immunity regulation, but the exact roles and mechanisms of Treg cells and MCs in B-cell non-Hodgkin's lymphoma (NHL) are incompletely defined. In the present study, we found that the number of Foxp3 Treg cells and CD117 MCs increased in B-cell NHL patients. Concomitantly, a high level of interleukin (IL)-9 was observed in the sera from B-cell NHL patients. Neutralizing IL-9 significantly inhibited tumor growth in the lymphoma model of murine, and this process was associated with down-regulation of Treg cells and MCs. Furthermore, IL-9 was also demonstrated to induce expression of MC-related genes and proliferation of MCs from the bone marrow stem cells. Collectively, our results indicate that Treg cell and MCs are involved in immunosuppression in B-cell NHL, and IL-9 is a key mediator of Treg cells and MCs in that process. These findings provide novel insight for the pathogenesis and possible therapeutic strategy of B-cell NHL.
- Subjects
LYMPHOMA treatment; TUMOR immunology; MAST cells; IMMUNOSUPPRESSION; INTERLEUKINS; TUMOR growth prevention; T cells; CELLULAR immunity
- Publication
Journal of Clinical Immunology, 2011, Vol 31, Issue 6, p1084
- ISSN
0271-9142
- Publication type
Article
- DOI
10.1007/s10875-011-9584-9