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- Title
Role of Prosopis cineraria against N-nitrosodiethylamine-induced liver tumor in rats with reference to marker enzymes and nucleic acid contents.
- Authors
Maideen, Naina Mohamed Pakkir; Velayutham, Ravichandiran; Manavalan, Gobinath
- Abstract
The effect of methanol extract of Prosopis cineraria against experimental liver tumor in rats was studied. Liver tumor was induced by the administration of N-nitrosodiethylamine (200 mg/kg) and it was promoted by phenobarbital administration. Methanol extract (200 and 400 mg/kg) was administered to determine the protective activity. Administration of methanol extract suppressed the liver tumor effectively as revealed by the decrease in elevated levels of aryl hydrocarbon hydroxylase, lactate dehydrogenase, γ-glutamyl transpeptidase (γ-GTP), 5'nudeotidase, deoxyribonudeic add (DNA) and ribonudeic acid (RNA). We found that methanol extract may extend its protective role by modifying the levels of marker enzymes and nucleic acid contents.
- Subjects
MESQUITE; LIVER tumors; TUMOR growth; LABORATORY rats; N-Nitrosodiethylamine; LACTATE dehydrogenase; HYDROXYLASES; NUCLEIC acids
- Publication
Bangladesh Journal of Pharmacology, 2011, Vol 6, Issue 2, p128
- ISSN
1991-007X
- Publication type
Article
- DOI
10.3329/bjp.v6i2.9027