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- Title
Ellagic Acid Inhibits Neuroinflammation and Cognitive Impairment Induced by Lipopolysaccharides.
- Authors
Dornelles, Guilherme Lopes; de Oliveira, Juliana Sorraila; de Almeida, Erin John Rieger; Mello, Camila Benaduce Emanuelli; e Rodrigues, Bernardo Rodrigues; da Silva, Cássia Bagolin; Petry, Letícia dos Santos; Pillat, Micheli Mainardi; Palma, Taís Vidal; de Andrade, Cinthia Melazzo
- Abstract
Neuroinflammation is a predisposing factor for the development of cognitive impairment and dementia. Among the new molecules that are currently being studied, ellagic acid (EA) has stood out for its neuroprotective properties. The present study investigated the effects of ellagic acid in the object recognition test, oxidative stress, cholinergic neurotransmission, glial cell expression, and phosphorylated Tau protein expression. For this, 32 male Wistar rats received an intraperitoneal (IP) application of lipopolysaccharides (LPS) at a dose of 250 µg/kg or 0.9% saline solution (SAL) for 8 days. Two hours after the IP injections, the animals received 100 mg/kg of EA or SAL via intragastric gavage. Behavioral parameters (open field test and object recognition) were performed on days 5, 6, and 7 of the experimental periods. The results showed that the treatment with EA in the LPS group was able to inhibit cognitive impairment, modulate the immune system response by significantly reducing glial cell expression, attenuating phosphorylated Tau and oxidative damage with consequent improvement in the antioxidant system, as well as preventing the increase of acetylcholinesterase activity. Thus, the neuroprotective effects of EA and its therapeutic potential in cognitive disorders secondary to neuroinflammation were demonstrated.
- Subjects
COGNITION disorders; ELLAGIC acid; INFLAMMATION; SALINE solutions; NEUROGLIA; LIPOPOLYSACCHARIDES; TAU proteins
- Publication
Neurochemical Research, 2020, Vol 45, Issue 10, p2456
- ISSN
0364-3190
- Publication type
Article
- DOI
10.1007/s11064-020-03105-z