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- Title
Interactive Effect of Probiotics Supplementation and Weight Loss Diet on Metabolic Syndrome Features in Patients With Coronary Artery Diseases: A Double-Blind, Placebo-Controlled, Randomized Clinical Trial.
- Authors
Moludi, Jalal; Alizadeh, Mohammad; Behrooz, Maryam; Maleki, Vahid; Seyed Mohammadzad, Mir Hossein; Golmohammadi, Ali
- Abstract
Background. Nutrition and probiotics supplementation are considered as nondrug strategies for the control of coronary artery disease (CAD). The aim of the present study was to investigate the interactive effects of probiotic supplementation and weight loss program on anthropometric and metabolic syndrome (MetS) indices in patients with CAD. Methods. A randomized, double-blind, placebo-controlled trial was performed in 44 overweight CAD patients. All the patients received weight loss program (5% to 10% of initial body weight) throughout the study course. The subjects were randomly assigned into intervention or placebo groups (n = 22, each) and received a probiotic or maltodextrin capsule/day, respectively, for 12 consecutive weeks. Anthropometric and MetS indices were assessed. Results. There was a significant decrease in total cholesterol (−30.7 ± 49.83 vs −5.9 ± 65 mmol/L, P =.043) and low-density lipoprotein cholesterol (−25.64 ± 51.7 vs −5.44 ± 70.1 mg/dL, P =.049) in the probiotic group compared to the placebo group. Other MetS feature indices and blood pressure did not differ significantly within or between groups. Conclusion. Probiotics supplementation improved total cholesterol and low-density lipoprotein cholesterol but had no effect on other lipid profile parameters and anthropometric indices. The weight loss diet plus probiotics supplementations resulted in more favorable decrease of cardiovascular risk factors compared to a weight loss program alone.
- Publication
American Journal of Lifestyle Medicine, 2021, Vol 15, Issue 6, p653
- ISSN
1559-8276
- Publication type
Article
- DOI
10.1177/1559827619843833