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- Title
Antifungal Resistance Mechanisms of Aspergillus.
- Authors
Jianjun Qiao; Wei Liu; Ruoyu Li
- Abstract
The incidence of invasive aspergillosis (IA), which is commonly caused by Aspergillus fumigatus, has increased recently in immunicompromised patients and has become the common cause of death in these patients. Antifungal resistance is one of the reasons for treatment failure. Since the first itraconazole-resistant A. fumigatus was reported in 1997, the reports on clinical strains of triazole-resistant A. fumigatus have increased, as well as studies on the resistant mechanisms. In this paper, the known molecular mechanisms of antifungal resistance in Aspergillus, especially in A. fumigatus, are reviewed.
- Subjects
ASPERGILLOSIS; ASPERGILLUS fumigatus; TRIAZOLES; ANTIFUNGAL agents; DRUG resistance in microorganisms; MYCOLOGY
- Publication
Japanese Journal of Medical Mycology, 2008, Vol 49, Issue 3, p157
- ISSN
0916-4804
- Publication type
Article
- DOI
10.3314/jjmm.49.157