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- Title
Family-Based Association Study of Chromosome 6p12.2-p21.1 Migraine Locus.
- Authors
Oterino, Agustín; Toriello, Maria; Castillo, Jesus; González-Quitanilla, Vicente; Sánchez-Velasco, Pablo; Alonso, Ana; Ruiz-Lavilla, Nuria; Pascual, Julio
- Abstract
Background.- One of the genome-wide linkage studies performed in migraine has yielded a significant linkage of migraine (with and without aura) with markers located at 6p12.2-21.1. This locus (named MIGR3) has not been replicated in the only genome-wide association scan study performed to date or in previous genome-wide linkage studies. Objective.- Our objective had been to replicate the MIGR3 locus performing a family-based association study. Methods.- A sample of 594 subjects belonging to 134 migraine families of diverse complexity underwent genotyping for the markers previously published as linked at 6p12.2-21.1 migraine locus. Family-based association test, under different models of inheritance, and also the model-free TDT analysis were performed. Results.- The best result was obtained with the D6S1650 marker under the additive model (rank [S observed] = 265.0; permuted P = .0006), using family-based association test program (HBAT subprogram). Similar results were obtained with the model-free TDTPHASE algorithm ( P < .0001, corrected). Nominal significant P values were obtained for D6S1630, D6S452, and D6S257. After correction for multiple testing with the stratified false-discovery rate, all markers showed significant association ( P < .0001). Conclusion.- We corroborated that the MIGR3 locus at 6p12 is a genetic risk for migraine with and without aura. ( Headache 2012;52:393-399)
- Subjects
MIGRAINE; BIOMARKERS; CHROMOSOMES; EPIDEMIOLOGY; GENEALOGY; GENES; GENETIC techniques; HUMAN genome; STATISTICAL power analysis; DATA analysis; DESCRIPTIVE statistics; GENETICS
- Publication
Headache: The Journal of Head & Face Pain, 2012, Vol 52, Issue 3, p393
- ISSN
0017-8748
- Publication type
Article
- DOI
10.1111/j.1526-4610.2011.02040.x