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- Title
Web Resources for HIV Type 1 Genotypic-Resistance Test Interpretation.
- Authors
Liu, Tommy F.; Shafer, Robert W.
- Abstract
Interpreting the results of plasma human immunodeficiency virus type 1 (HIV-1) genotypic drug-resistance tests is one of the most difficult tasks facing clinicians caring for HIV-1-infected patients. There are many drug-resistance mutations, and they arise in complex patterns that cause varying levels of drug resistance. In addition, HIV-1 exists in vivo as a virus population containing many genomic variants. Genotypic-resistance testing detects the drug-resistance mutations present in the most common plasma virus variants but may not detect drug-resistance mutations present in minor virus variants. Therefore, interpretation systems are necessary to determine the phenotypic and clinical significance of drug-resistance mutations found in a patient's plasma virus population. We describe the scientific principles of HIV-1 genotypic-resistance test interpretation and the most commonly used Web-based resources for clinicians ordering genotypic drug-resistance tests.
- Subjects
ONLINE information services; PUBLIC health communication; HIV-positive persons; DRUG resistance; COMPUTER network resources; INFORMATION storage &; retrieval systems -- Public health; HEALTH education
- Publication
Clinical Infectious Diseases, 2006, Vol 42, Issue 11, p1608
- ISSN
1058-4838
- Publication type
Article
- DOI
10.1086/503914