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- Title
HLA-D/DR Restriction of Langerhans Cell-Dependent Antigen Activation of T Lymphocytes.
- Authors
Berle, E. J.; Braathen, L. R.; Thorsby, E.
- Abstract
In previous studies we have shown that the response of T cells to antigen presented by epidermal Langerhans cells (LC) is restricted by products of the HLA-D region. An optimal antigen-specific response required that the LC used for antigen presentation shared both, or at least one, of the D/DR determinants of the T-cell donor. These studies were, however, disturbed by a strong allogeneic response induced by the foreign D/DR, determinants of the LC. We report here that by separating the antigen-specific T cells from those that are alloreactive, a clearer picture of the D/DR restriction phenomenon may be obtained. Furthermore, the present studies demonstrate that the same D/DR determinants function as restriction elements on peripheral blood monocytes and LC..
- Subjects
T cells; LANGERHANS cells; IMMUNE response; HLA histocompatibility antigens; ANTIGEN-antibody reactions; IMMUNOLOGY
- Publication
Scandinavian Journal of Immunology, 1982, Vol 16, Issue 6, p549
- ISSN
0300-9475
- Publication type
Article
- DOI
10.1111/j.1365-3083.1982.tb00758.x