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- Title
Thoracic bilateral sympathectomy attenuates oxidative stress and prevents ventricular remodelling in experimental pulmonary hypertension.
- Authors
Silva, Raphael dos Santos Coutinho e; Wiggenhauser, Lucas Moritz; Simas, Rafael; Zanoni, Fernando Luiz; Medeiros, Geisla; Silva, Fernanda Beatriz da; Ogata, Daniel Cury; Breithaupt-Faloppa, Ana Cristina; Krenning, Guido; Moreira, Luiz Felipe Pinho
- Abstract
Open in new tab Download slide Open in new tab Download slide OBJECTIVES Pulmonary arterial hypertension (PAH) is a cardiopulmonary disease that affects the pulmonary vasculature, leading to increased afterload and eventually right ventricular (RV) remodelling and failure. Bilateral sympathectomy (BS) has shown promising results in dampening cardiac remodelling and dysfunction in several heart failure models. In the present study, we investigated whether BS reduces pulmonary arterial remodelling and mitigates RV remodelling and failure. METHODS PAH was induced in male Wistar rats by intraperitoneal injection of monocrotaline. Rats were divided into 3 groups, involving untreated PAH (n = 15), BS-treated PAH (n = 13) and non-manipulated control rats (n = 13). Three weeks after PAH induction, the rats were anaesthetized and RV function was assessed via the pressure-volume loop catheter approach. Upon completion of the experiment, the lungs and heart were harvested for further analyses. RESULTS BS was found to prevent pulmonary artery remodelling, with a clear reduction in α-smooth muscle actin and endothelin-1 expression. RV end-systolic pressure was reduced in the BS group, and preload recruitable stroke work was preserved. BS, therefore, mitigated RV remodelling and cardiomyocyte hypertrophy and diminished oxidative stress. CONCLUSIONS We showed that thoracic BS may be an important treatment option for PAH patients. Blockade of the sympathetic pathway can prevent pulmonary remodelling and protect the RV from oxidative stress, myocardial remodelling and function decay.
- Subjects
VENTRICULAR remodeling; PULMONARY hypertension; OXIDATIVE stress; VASCULAR remodeling; RIGHT ventricular hypertrophy; HEART failure; PULMONARY arterial hypertension
- Publication
European Journal of Cardio-Thoracic Surgery, 2022, Vol 61, Issue 6, p1337
- ISSN
1010-7940
- Publication type
Article
- DOI
10.1093/ejcts/ezab549