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- Title
The Role of UVB Radiation in the Induction and Elicitation of Photocontact Hypersensitivity to TCSA in the Mouse.
- Authors
Granstein, Richard D.; Morison, Warwick L.; Kripke, Margaret L.
- Abstract
Photocontact hypersensitivity (PHS) to 3,3',4',5 tetrachlorosalicylanilide (TCSA) can be induced in mice by using cyclophosphamide as an immunopotentiator. Only UVA (320-400 nm) radiation was required for both sensitization and elicitation of PHS. The reaction was successfully transferred to syngeneic mice by injecting them with lymph node cells from sensitized donors, a finding that demonstrates the immunologic nature of PHS. The presence of UVB (280-320 nm) radiation was not necessary for sensitization and did not increase PHS beyond the levels observed with UVA radiation alone. Ultraviolet radiation in the UVB range (plus a small amount of UVA radiation) from FS4O sunlamps in the dose employed did not induce statistically significant PHS to TCSA, nor did it elicit a significant response in mice sensitized with TCSA plus UVA radiation. However, treatment of mice with UVB radiation at a distant site 6 days before sensitization suppressed the induction of PHS. This suppression appeared to be analogous to the systemic suppression of ordinary contact hypersensitivity in mice by UVB radiation.
- Subjects
PHOTOSENSITIVITY disorders; SKIN inflammation; ALLERGIES; IMMUNOLOGICAL adjuvants; RADIATION injuries; ULTRAVIOLET radiation
- Publication
Journal of Investigative Dermatology, 1983, Vol 80, Issue 3, p158
- ISSN
0022-202X
- Publication type
Article
- DOI
10.1111/1523-1747.ep12533301