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- Title
Six new loci controlling resistance to p-fluorophenylalanine in Aspergillus nidulans.
- Authors
Srivastava, Sheela; Sinha, Umakant
- Abstract
Twelve FPA-resistant mutants were selected on medium containing p-fluorophenylalanine and ethionine. Dominance tests in heterozygous diploids showed that 8 out of 12 are dominant and 4 recessive to their wild-type alleles. One mutant, fpa60, showed a partial requirement for tyrosine and was found to be allelic to an fpaA mutant described previously. A tyrosine non-requirer, fpa65, was also assigned to this locus. The other 10 mutants did not show any growth requirement and were simultaneously resistant to ethionine and 3-amino-L-tyrosine. Of the 8 dominant mutants, 3 were allelic to the permease-mutants at the locus fpaD. Dominant mutants showed higher degrees of resistance than recessive ones. Six new loci, identified after preliminary genetic analysis, were located on 3 linkage groups: 3 on linkage group VI, and one each on linkage groups I, V, and VIII. The recombinant fpaD11; fpaK69 was found to be sensitive to FPA.
- Publication
Genetics Research, 1975, Vol 25, Issue 1, p29
- ISSN
0016-6723
- Publication type
Article
- DOI
10.1017/S0016672300015408