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- Title
Pulmonary function in thalassaemia major and its correlation with body iron stores.
- Authors
Sohn, Eugene Y.; Noetzli, Leila J.; Gera, Aakanksha; Kato, Roberta; Coates, Thomas D.; Harmatz, Paul; Keens, Thomas G.; Wood, John C.
- Abstract
Summary This study compared pulmonary function tests (PFTs) with cardiac, pancreatic and liver iron in 76 thalassemia major (TM) patients. Restrictive lung disease was observed in 16%, hyperinflation in 32% and abnormal diffusing capacity in 3%. While no patients met Global Initiative for Chronic Lung Disease criteria for airways obstruction, there were indicators of small airways disease and air trapping. PFTs did not correlate with somatic iron burden, blood counts or haemolysis. Restrictive lung disease was associated with inflammation. We conclude that TM patients have pulmonary abnormalities consistent with small airways obstruction. Restrictive disease and impaired diffusion are less common.
- Subjects
LUNG diseases; PULMONARY function tests; PATHOLOGICAL physiology; ANTI-inflammatory agents; INFLAMMATION; HEMOLYSIS &; hemolysins
- Publication
British Journal of Haematology, 2011, Vol 155, Issue 1, p102
- ISSN
0007-1048
- Publication type
Article
- DOI
10.1111/j.1365-2141.2011.08808.x