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- Title
A new genetic lesion in B-CLL: a NOTCH1 PEST domain mutation.
- Authors
Di Ianni, Mauro; Baldoni, Stefano; Rosati, Emanuela; Ciurnelli, Raffaella; Cavalli, Laura; Martelli, Massimo F.; Marconi, PierFrancesco; Screpanti, Isabella; Falzetti, Franca
- Abstract
The article reports on a study determining whether NOTCH1 activating mutations are present in B-chronic lymphocytic leukemia (B-CLL) cells. As reported, Notch1 and Notch2 constitutive activation plays a critical role in survival and apoptosis resistance of B-CLL cells. It has been suggested in the study that for T-cell acute lymphoblastic leukemia (T-ALL), deletions of the COOH-terminal sequences in the PEST domain could enhance Notch-IC stability and signalling.
- Subjects
CHRONIC lymphocytic leukemia; CHRONIC diseases; LYMPHOBLASTIC leukemia; LYMPHOPROLIFERATIVE disorders; APOPTOSIS
- Publication
British Journal of Haematology, 2009, Vol 146, Issue 6, p689
- ISSN
0007-1048
- Publication type
Letter
- DOI
10.1111/j.1365-2141.2009.07816.x