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- Title
Misoprostol and Ranitidine in the Prevention of NSAID-Induced Ulcers: A Prospective, Double-Blind, Multicenter Study.
- Authors
Raskin, Jeffrey B.; White, Richard H.; Jaszewski, Richard; Korsten, Mark A.; Schubert, Timothy T.; Fort, John G.
- Abstract
Objective: To compare ranitidine to misoprostol with respect to the prevention of gastric and duodenal ulcers in patients on chronic NSAID therapy. Methods: A multi-center, 8-wk, randomized, double-blind study. Eligible patients were on chronic NSAID therapy and were experiencing NSAID-related upper gastrointestinal (UGI) pain without UGI endoscopic evidence of gastric or duodenal ulcers. Patients enrolled in the study were randomized to either misoprostol 200 µg <em>q.i.d.</em> or ranitidine 150 mg <em>b.i.d.</em>. Follow-up UGI endoscopy was performed after 4 and 8 wk of treatment. Therapeutic failure was considered the development of a gastric or duodenal ulcer ≥ 0.3 cm in diameter with perceptible depth. Results: Gastric ulcers were found in only 1/180 (0.56%) patient on misoprostol and in 11/194 (5.67%) patients on ranitidine, a difference that was statistically significant (<em>p</em> < 0.01). Duodenal ulcer rates were similar for the ranitidine (2/185 or 1.08%) and misoprostol (2/ 181 or 1.10%) groups. Conclusion: Misoprostol is significantly more effective than ranitidine in the prevention of NSAID-induced gastric ulcers. Ranitidine was as effective as misoprostol for the prevention of NSAID-induced duodenal ulcers. Misoprostol should be used for prophylaxis against both gastric and duodenal ulceration in patients on chronic NSAID therapy.
- Subjects
RANITIDINE; ANTIULCER drugs; GASTROINTESTINAL agents; NONSTEROIDAL anti-inflammatory agents; ULCERS
- Publication
American Journal of Gastroenterology (Springer Nature), 1996, Vol 91, Issue 2, p223
- ISSN
0002-9270
- Publication type
Article