We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
A Pilot Study of Splenic and Whole Body Retention of Autologous Radiolabeled Leukocytes in the Assessment of Severity in Inflammatory Colitis.
- Authors
Rowe, F. Anderson; Camilleri, Michael; Forstrom, Lee A.; Batts, Kenneth P.; Mullan, Brian P.; Thomforde, George M.; Dunn, William; Zinsmeister, Alan R.
- Abstract
Objective: To assess the splenic and whole body retention of radiolabeled autologous leukocytes over 24 or 48 h as measures of the severity of colitis. Methods: Eleven patients with colitis underwent standardized clinical, endoscopic, histological, and 111In-labeled leukocyte scintigraphy. A logistic discriminant analysis was used to estimate weighting factors for morphological indices, serum albumen, and stool excretion of 111 In over 24 h that predicted the clinical assessment of severity. Subsequently, Spearman rank correlation analysis estimated associations among reductions in spleen and whole body radioactivity and the derived indices of inflammation. Results: The reduction in spleen counts over 24 h correlates significantly with morphological indices (r8 = 0.83, <em>p</em> < 0.005) and with serum albumen and stool 111 In (functional index, rs = 0.77, <em>p</em> < 0.01). Similarly, the reduction in whole body 111 In over 48 h correlates significantly with the combined index (rs = 0.8) and with the morphological and functional index separately (rs = 0.72 and 0.79, respectively). Conclusion: This pilot study identified weighting factors for morphological and functional indices in assessing severity of colitis; reduction in whole body and splenic retention of radioactivity was sufficient for evaluation of severity of colitis without the need for stool collections.
- Subjects
RADIOLABELED leucocytes; LEUCOCYTES; COLITIS; RADIONUCLIDE imaging; SPLEEN
- Publication
American Journal of Gastroenterology (Springer Nature), 1995, Vol 90, Issue 10, p1771
- ISSN
0002-9270
- Publication type
Article