We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Anti-glycation and antioxidant effects of Chaga mushroom decoction extracted with a fermentation medium.
- Authors
Naoki DOI; Kazuichi ARAKI; Yoichiro FUKUTA; Yudai KUWAGAITO; Yukinori YAMAUCHI; Yasushi SASAI; Shin-ichi KONDO; Masayuki KUZUYA
- Abstract
Glycation reactions between proteins and sugars or their metabolites produce advanced glycation endproducts, and the glycation of collagen in normal human dermal fibroblasts (NHDF) causes skin spots and freckles. UV exposure induces oxidative stress in NHDF, which overexpresses enzymes that degrade collagen, resulting in dry skin and wrinkling. Herein, we produced a novel polyphenolic decoction of Chaga mushroom extracted with a fermentation medium. Chaga polyphenol decoction (CPD) inhibited the glycation of albumin and collagen gel 3 to 4 times more than 2-aminoguanidine. The antioxidant effects of CPD were investigated using the fluorescence of an intracellular reactive oxygen species (ROS) scavenger, and NHDF exposed to UV-A for 60 min (9.5 J/cm²) after pre-treatment with 190 µg/mL of CPD suppressed ROS scavenger emission by 50 % compared to treatment with phosphate buffer saline. These results suggest that CPD might be a promising glycation inhibitor and ROS scavenger.
- Subjects
WRINKLES (Skin); REACTIVE oxygen species; MUSHROOMS; RECEPTOR for advanced glycation end products (RAGE); ANTIOXIDANTS; COLLAGEN; SERUM albumin
- Publication
Food Science & Technology Research, 2023, Vol 29, Issue 2, p155
- ISSN
1344-6606
- Publication type
Article
- DOI
10.3136/fstr.FSTR-D-22-00120