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- Title
Correlates of Skeletal Muscle Mass and Differences Between Novel Subtypes in Recent-Onset Diabetes.
- Authors
Herder, Christian; Maalmi, Haifa; Saatmann, Nina; Zaharia, Oana-Patricia; Strassburger, Klaus; Burkart, Volker; Norman, Kristina; Roden, Michael
- Abstract
Context: Low skeletal muscle mass (SMM) is associated with long-standing diabetes but little is known about SMM in newly diagnosed diabetes. Objective: We aimed to identify correlates of SMM in recent-onset diabetes and to compare SMM between novel diabetes subtypes. Methods: SMM was normalized to body mass index (SMM/BMI) in 842 participants with known diabetes duration of less than 1 year from the German Diabetes Study (GDS). Cross-sectional associations between clinical variables, 79 biomarkers of inflammation, and SMM/BMI were assessed, and differences in SMM/BMI between novel diabetes subtypes were analyzed with different degrees of adjustment for confounders. Results: Male sex and physical activity were positively associated with SMM/BMI, whereas associations of age, BMI, glycated hemoglobin A1c, homeostatic model assessment for β-cell function, and estimated glomerular filtration rate with SMM/BMI were inverse (all P < .05; model r² = 0.82). Twenty-three biomarkers of inflammation showed correlations with SMM/BMI after adjustment for sex and multiple testing (all P < .0006), but BMI largely explained these correlations. In a sex-adjusted analysis, individuals with severe autoimmune diabetes had a higher SMM/BMI whereas individuals with severe insulin-resistant diabetes and mild obesity-related diabetes had a lower SMM/BMI than all other subtypes combined. However, differences were attenuated after adjustment for the clustering variables. Conclusion: SMM/BMI differs between diabetes subtypes and may contribute to subtype differences in disease progression. Of note, clinical variables rather than biomarkers of inflammation explain most of the variation in SMM/BMI.
- Subjects
SKELETAL muscle; MUSCLE mass; DIABETES
- Publication
Journal of Clinical Endocrinology & Metabolism, 2024, Vol 109, Issue 3, pe1238
- ISSN
0021-972X
- Publication type
Article
- DOI
10.1210/clinem/dgad605