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- Title
One Year of GH Treatment for Growth Failure in Children With Anorexia Nervosa: A Randomized Placebo-Controlled Trial.
- Authors
Léger, Juliane; Fjellestad-Paulsen, Anne; Bargiacchi, Anne; Pages, Justine; Chevenne, Didier; Alison, Marianne; Alberti, Corinne; Guilmin-Crepon, Sophie; Justine, Pages
- Abstract
<bold>Context: </bold>Children with anorexia nervosa (AN) are at risk of adult height deficit due to prolonged low height velocity (HV).<bold>Objective: </bold>To investigate the effects of human growth hormone (GH) injections on HV in children with AN and severe growth impairment.<bold>Design and Participants: </bold>In this prospective, randomized, double-blind, single-center, proof-of-concept trial, children with AN and low HV (≤2 cm/year) for at least 18 months, and a bone age ≤12 years for girls and ≤14 years for boys, were randomized to receive daily subcutaneous injections of human GH (0.050 mg/kg/day) or placebo for 12 months.<bold>Main Outcome Measures: </bold>Change in HV after 12 months.<bold>Results: </bold>In total, 8 patients were assigned to the GH group and 6 to the placebo group. Patients had a median (25th-75th percentile) HV of 1.0 (0.5;1.5) cm/year. The effect of GH treatment increased strongly after 6 months, with a height gain after 12 months of 9.65 (8.0;11.6) cm for the GH group vs 3.85 (1.7;7.3) cm for the placebo group, with an absolute median (2.5th-97.5th percentile) difference between the groups of 5.8 (-1.85;9.68) cm after bootstrapping. The percentage of patients with a HV > 5 cm/year during the study period was higher in the GH group than in the placebo group (100% vs 50%, P = 0.05). Adverse events occurred in similar numbers in the 2 groups, were mild or nonfatal, and did not lead to treatment being stopped.<bold>Conclusion: </bold>GH administration to improve HV is a potentially valid option for increasing HV in children with AN and prolonged severe growth failure.
- Subjects
PITUITARY dwarfism; TREATMENT failure; ANOREXIA nervosa; GROWTH of children; INSULIN-like growth factor-binding proteins; HUMAN body composition; CALCIUM metabolism; ADIPOSE tissues; ANOREXIA nervosa complications; STATURE; HUMAN growth hormone; TREATMENT effectiveness; COMPARATIVE studies; RANDOMIZED controlled trials; BLIND experiment; STATISTICAL sampling; GROWTH disorders; SUBCUTANEOUS injections; LONGITUDINAL method
- Publication
Journal of Clinical Endocrinology & Metabolism, 2021, Vol 106, Issue 7, pe2535
- ISSN
0021-972X
- Publication type
journal article
- DOI
10.1210/clinem/dgab203