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- Title
Stepwise diet management in pediatric gastrointestinal graft versus host disease.
- Authors
Koç, Nevra; Gündüz, Mehmet; Fatih Azık, M.; Tavil, Betül; Gürlek-Gökçebay, Dilek; Özaydın, Eda; Tunç, Bahattin; Uçkan, Duygu
- Abstract
Gastrointestinal tract is one of the major systems affected by graft-versus-host disease (GVHD). Injury to the gut during conditioning therapy before stem-cell transplantation (SCT) plays a pivotal role in the initiation of inflammatory stimuli. We reviewed medical records of the patients who underwent SCT between April 2010 and June 2013 in our center. A stepwise upgrade diet was given to the children with acute GI-GVHD (Gastrointestinal GVHD) including parenteral and enteral nutrition. A total of 105 patients underwent SCT and seven patients developed grade III-IV acute GI-GVHD. Total parenteral nutrition (TPN) was initiated to all patients after the diagnosis of GI-GVHD and minimal enteral nutrition (1-2 ml/kg/day standard pediatric enteral formula/special meat soup) was given to the patients. GI-GVHD improved in all patients with no change in body weight, and recovery to a normal diet took 10-30 days. Stepwise diet management of oral nutrition contributed to rapid improvement of grades III-IV acute GI-GVHD.
- Subjects
DIET therapy; GASTROINTESTINAL diseases; GRAFT versus host disease; CHILD nutrition; STEM cell transplantation; PREOPERATIVE care
- Publication
Turkish Journal of Pediatrics, 2016, Vol 58, Issue 2, p145
- ISSN
0041-4301
- Publication type
Article
- DOI
10.24953/turkjped.2016.02.004