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- Title
NMR-Based Metabonomic Studies on Stomach Heat and Cold Syndromes and Intervention Effects of the Corresponding Formulas.
- Authors
Zhongjie Zou; Bin Han; Mengjuan Gong; Shumei Wang; Shengwang Liang
- Abstract
Zuojin Wan (ZJW) and Lizhong Wan (LZW) have been widely used in the treatment of Stomach heat and cold syndrome (SH and SC), respectively. In this study, a proton nuclear magnetic resonance (1H NMR) based metabonomic approach was developed to profile SH and SC-related metabolic perturbations in rat serum and to investigate the intervention effects of ZJW and LZW on the corresponding SH and SC. Compared to the conventional macroscopic and histopathological examinations, the metabonomic approach could enable discrimination between SH and SC based on serum metabolic profiles. Meanwhile, 17 and 15 potential biomarkers associated with SH and SC, respectively, which were mainly involved in gastric dysfunction and mucosal lesions, gut microbiotal activity, transmethylation, glucose and lipid metabolism, and amino acid metabolism, were identified. Furthermore, taking the potential biomarkers as drug targets, it was revealed that administration of ZJW and LZW could exclusively reverse the pathological process of SH and SC, respectively, through partially regulating the disturbed metabolic pathways. This work showed biological basis related to SH and SC at metabolic level and offered a new paradigm for better understanding and explanation of "Fang Zheng Dui Ying" principle in traditional Chinese medicine from a systemic view.
- Subjects
CHINA; ANALYSIS of variance; ANIMAL experimentation; BIOMARKERS; COMBINATION drug therapy; DIFFERENTIAL diagnosis; DIGESTIVE system diseases; FACTOR analysis; GOODNESS-of-fit tests; HERBAL medicine; CHINESE medicine; MICROSCOPY; RATS; RESEARCH funding; SPECTRUM analysis; STATISTICS; DATA analysis; DATA analysis software; DESCRIPTIVE statistics; THERAPEUTICS
- Publication
Evidence-based Complementary & Alternative Medicine (eCAM), 2014, Vol 2014, p1
- ISSN
1741-427X
- Publication type
Article
- DOI
10.1155/2014/528396