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- Title
Analysis of Axillary Lymph Nodes in Breast Cancer Patients with Positive Sentinel Lymph Node Biopsy.
- Authors
Grebić, D.; Grbas, H.; Zujić, P. V.; Mavrić, M.; Tomašić, A. M.
- Abstract
Objective: To determine the prevalence of positive non-sentinel nodes (non-SLN) after axillary dissection for positive sentinel lymph node (SLN) and the relationship between occurrence of positive non-SLNs and penetration of the sentinel's capsule by malignant cells, as well as grade and molecular subtype of the breast cancer. Methods: An analysis was performed of a total of 77 patients with a positive SLN from a five-year period. Patients were categorized according to the following criteria: positivity of non-SLN, invasion of SLN capsule, tumour grade, T stage and molecular subtype. Results: In over 65% of patients, non-SLNwere negative for metastases despite a positive SLN. A statistically significant correlation was observed between SLN capsule penetration and positive non-SLN metastases (p < 0.001). It was also observed that non-SLN metastases are more commonly positive in patients with a high tumour grade, high T stage, and HER2-positive and triple-negative tumours. Conclusion: Non-SLN metastases are generally found in patients with SLN capsule penetration by malignant cells, in those with poorly differentiated tumours (high grade), and in those with high T stage, as well as in triple-negative and HER2-positive tumours. Based on these findings, such patients should undergo axillary dissection due to an increased risk of non-SLN metastases.
- Subjects
SENTINEL lymph node biopsy; LYMPH node cancer; SENTINEL lymph nodes; CANCER patients; CANCER cell growth; CANCER cells
- Publication
West Indian Medical Journal, 2024, Vol 71, Issue 1, p9
- ISSN
0043-3144
- Publication type
Article
- DOI
10.7727/wimj.2017.092