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- Title
Diagnostic Value of p16 Methylation for Malignant Pleural Effusion AMeta-analysis.
- Authors
Li, M.; Guo, S.-J.; Shen, Y.-C.; Jia, L.-Q.; Li, D.-D.; Wan, C.; Wen, F.-Q.
- Abstract
Objective: To evaluate the overall diagnostic performance of the p16 methylation for diagnosing malignant pleural effusion (MPE). Methods: All published literature in English and Chinese were reviewed. Sensitivity, specificity, likelihood ratio and diagnostic odds ratio (DOR) were pooled by using random-effects model or fixedeffects model. Summary receiver operating characteristic (SROC) curve was used to evaluate the overall diagnostic value. Results: Six studies were included with a total of 378 cases. The sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR) and DOR of p16 methylation in the diagnosis of MPE were 0.41 [95% confidence interval (CI) 0.35, 0.48], 0.97 [95% CI 0.93, 0.99], 9.57 [95% CI 4.53, 20.20], 0.61 [95% CI 0.45, 0.82] and 19.82 [95% CI 8.35, 47.04], respectively. The area under the curve (AUC) was 0.864. Conclusion: Pleural p16 methylation test plays a useful role in the diagnosis of MPE.
- Subjects
PLEURAL effusions; METHYLATION; CANCER diagnosis; MEDICAL statistics; META-analysis; DIAGNOSIS
- Publication
West Indian Medical Journal, 2013, Vol 62, Issue 8, p716
- ISSN
0043-3144
- Publication type
Article