We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Alpha-synuclein is present in dental calculus but not altered in Parkinson’s disease patients in comparison to controls.
- Authors
Schmid, Sabrina; Goldberg-Bockhorn, Eva; Schwarz, Silke; Rotter, Nicole; Kassubek, Jan; Del Tredici, Kelly; Pinkhardt, Elmar; Otto, Markus; Ludolph, Albert C.; Oeckl, Patrick
- Abstract
Introduction: In autopsy cases staged for sporadic Parkinson’s disease (PD), the neuropathology is characterized by a preclinical phase that targets the enteric nervous system of the gastrointestinal tract (GIT). Therefore, the ENS might be a source of potential (presymptomatic) PD biomarkers.Methods: In this clinically based study, we examined the alpha-synuclein (αSyn) concentration in an easily accessible protein storage medium of the GIT, dental calculus, in 21/50 patients with PD and 28/50 age- and gender-matched controls using ELISA.Results: αSyn was detectable in dental calculus and the median concentration in the control patients was 8.6 pg/mg calculus (interquartile range 2.6-13.1 pg/mg). αSyn concentrations were significantly influenced by blood contamination and samples with a hemoglobin concentration of > 4000 ng/mL were excluded. There was no significant difference of αSyn concentrations in the dental calculus of PD patients (5.76 pg/mg, interquartile range 2.91-9.74 pg/mg) compared to those in controls (p = 0.40).Conclusion: The total αSyn concentration in dental calculus is not a suitable biomarker for sporadic PD. Disease-related variants such as oligomeric or phosphorylated αSyn in calculus might prove to be more specific.
- Subjects
PARKINSON'S disease; NEUROLOGICAL disorders; SYNUCLEINS; ENZYME-linked immunosorbent assay; HEMOGLOBINS; BIOLOGICAL tags
- Publication
Journal of Neurology, 2018, Vol 265, Issue 6, p1334
- ISSN
0340-5354
- Publication type
Article
- DOI
10.1007/s00415-018-8847-2