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- Title
Differences in extraction methods to antidiarrheal activity in vitro and in vivo in unripe Kayu banana fruit (Musa paradisiaca L. Var. Kayu).
- Authors
Ningsih, Arista Wahyu; Pratama, Edo; Komariyah, Siti; Astuti, Diah Putri; Klau, Ivan Charles S.; Rahmawati, Dewi
- Abstract
Introduction: Kayu banana is a fruit found in Lumajang Regency, East Java, with antidiarrheal activity. Phenolic compounds in the unripe Kayu banana fruit have antidiarrheal activity in vivo and in vitro. This study aimed to prove the effectiveness of the extraction method on the phenolic acid content of the unripe Kayu banana fruit (Musa paradisiaca L. var. Kayu) as an antidiarrheal drug and to determine the significant difference between the extraction method on the phenolic acid content and antidiarrheal activity of the unripe Kayu banana fruit (Musa paradisiaca L. var. Kayu). Methods: The research method used is an experimental quantitative method. There are 2 extraction methods used in this study, namely: cold extraction (remaceration and maceration) and hot extraction (reflux and Soxhlet). Results: The results obtained in the extraction method with the remaceration extraction method were 99.31±1.11 mg GAE/g, with the highest antidiarrheal activity at the average marker trajectory. The Soxhlet extraction method has the highest antibacterial activity with an average inhibition zone of 24 0.82 mm. Conclusion: Differences in extraction methods affect the phenolic levels of the extract and the antidiarrheal activity in vitro and in vivo in the raw fruit extract of banana wood. Based on the percentage of inhibition produced by the extract of the unripe fruit of the wood banana (Musa paradisiaca L. Var. Kayu), the extraction method of remacetation was 55.82 %, with the highest phenolic content. The soxhlet method has the highest antidiarrheal activity.
- Subjects
JAWA Timur (Indonesia); ANTIDIARRHEALS; BANANAS; FRUIT extracts; PHENOLS
- Publication
Gaceta Médica de Caracas, 2022, Vol 130, pS1133
- ISSN
0367-4762
- Publication type
Article
- DOI
10.47307/GMC.2022.130.s5.38