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- Title
Iron deficiency in Yemeni patients with sickle-cell disease.
- Authors
Kassim, A.; Thabet, S.; Al-Kabban, M.; Al-Nihari, K.
- Abstract
Despite the general view that patients with sickle-cell disease (SCD) have iron overload, there are reports of iron deficiency in a proportion of these patients. We studied Yemeni patients aged 1-30 years with homozygous SCD to determine their iron status using a set of 4 criteria (low serum iron, low transferrin saturation, high total iron binding capacity and low mean corpuscular volume for age). Of the 75 patients, 44 had never been transfused while 31 patients had received blood transfusions but not during the 3-month period prior to the study. Of the patients, 10 (13.3%) met the criteria for iron deficiency, 9 of whom were from the non-transfused patients (20.5%). The sensitivity and specificity were 40% and 98% respectively for reticulocyte count and 80% and 90% respectively for reticulocyte index. We recommend screening non-transfused SCD patients for iron deficiency.
- Subjects
YEMEN (Republic); IRON deficiency anemia diagnosis; ANALYSIS of variance; BLOOD transfusion; BLOOD cell count; ELECTROPHORESIS; IRON deficiency anemia; RETICULOCYTES; SICKLE cell anemia; T-test (Statistics); DATA analysis software; DESCRIPTIVE statistics; DISEASE risk factors
- Publication
Eastern Mediterranean Health Journal, 2012, Vol 18, Issue 3, p241
- ISSN
1020-3397
- Publication type
Article
- DOI
10.26719/2012.18.3.241