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- Title
Stereospecific Biosynthesis of β-Methyltryptophan from L-Tryptophan Features a Stereochemical Switch.
- Authors
Zou, Yi; Fang, Qi; Yin, Haixing; Liang, Zutao; Kong, Dekun; Bai, Linquan; Deng, Zixin; Lin, Shuangjun
- Abstract
Wahlweise: Die Drei ‐ Enzyme ‐ Kassette MarG/H/I steuert die stereospezifische Biosynthese von β ‐ Methyltryptophan aus L ‐ Tryptophan (1). MarG/I wandelt 1 in (2S,3R) ‐ β ‐ Methyltryptophan um, während MarG/I in Kombination mit MarH aus 1 das (2S,3S) ‐ β ‐ Methyltryptophan erzeugt. MarH dient als stereochemischer Schalter, indem es die Inversion des β ‐ Stereozentrums katalysiert.
- Subjects
REACTION mechanisms (Chemistry); BIOSYNTHESIS; STEREOSPECIFICITY; TRYPTOPHAN; GENE cassettes; CHEMICAL research
- Publication
Angewandte Chemie, 2013, Vol 125, Issue 49, p13189
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201306255