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- Title
Incidental detection of premature centromere separation in amniocytes associated with a mild form of Roberts syndrome.
- Authors
Stanley, Wayne S.; Pai, G. Shashidhar; Horger, Edgar O.; Yongshan, Yan; McNeal, Karen S.
- Abstract
Premature centromere separation (PCS) was detected in amniocytes after an amniocentesis was done because of markedly elevated maternal serum alpha-fetoprotein values in a healthy primiparous young woman. PCS has been associated with the Roberts-SC phocomelia syndrome (RS). By 23 weeks' gestation, ultrasonic evaluations did not reveal abnormal fetal development. The pregnancy continued and a male infant was born with mild manifestations of RS. PCS was confirmed in cord blood lymphocytes. This case illustrates that PCS, when detected in amniotic fluid cell cultures, requires a thorough evaluation.
- Publication
Prenatal Diagnosis, 1988, Vol 8, Issue 8, p565
- ISSN
0197-3851
- Publication type
Article
- DOI
10.1002/pd.1970080803