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- Title
Decoding the role of aberrant RNA alternative splicing in hepatocellular carcinoma: a comprehensive review.
- Authors
Sheng, Mengfei; Zhang, Yuanyuan; Wang, Yaoyun; Liu, Weiyi; Wang, Xingyu; Ke, Tiaoying; Liu, Pingyang; Wang, Sihan; Shao, Wei
- Abstract
During eukaryotic gene expression, alternative splicing of messenger RNA precursors is critical in increasing protein diversity and regulatory complexity. Multiple transcript isoforms could be produced by alternative splicing from a single gene; they could eventually be translated into protein isoforms with deleted, added, or altered domains or produce transcripts containing premature termination codons that could be targeted by nonsense-mediated mRNA decay. Alternative splicing can generate proteins with similar, different, or even opposite functions. Increasingly strong evidence indicates that abnormal RNA splicing is a prevalent and crucial occurrence in cellular differentiation, tissue advancement, and the development and progression of cancer. Aberrant alternative splicing could affect cancer cell activities such as growth, apoptosis, invasiveness, drug resistance, angiogenesis, and metabolism. This systematic review provides a comprehensive overview of the impact of abnormal RNA alternative splicing on the development and progression of hepatocellular carcinoma.
- Subjects
ALTERNATIVE RNA splicing; HEPATOCELLULAR carcinoma; RNA splicing; STOP codons; CANCER cell growth; WARBURG Effect (Oncology); DRUG metabolism
- Publication
Journal of Cancer Research & Clinical Oncology, 2023, Vol 149, Issue 19, p17691
- ISSN
0171-5216
- Publication type
Article
- DOI
10.1007/s00432-023-05474-8