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- Title
Somatostatin-analog effect on pancreatic fistula after radical gastrectomy: a pilot randomized controlled trial.
- Authors
Sha, Shengxu; Qiao, Wenhao; Feng, Renxiang; Lian, Guodong; Chen, Yuezhi; Peng, Lipan; Wang, Junke; Li, Leping; Tian, Feng; Jing, Changqing
- Abstract
Purpose: Radical gastrectomy with D2 lymphadenectomy can trigger a high incidence of postoperative pancreatic fistula (POPF), which produces a poor clinical prognosis. We sought to evaluate the effect of somatostatin analogs (SSA) on POPF and clinical prognosis after radical gastrectomy. Methods: A total of 123 patients with a high risk of POPF after radical gastrectomy (drainage fluid amylase concentration on a postoperative day [POD] 1 > 3 times the upper limit of normal serum amylase value) were randomly divided into the SSA group (n = 61) and the control group (n = 62). The former received continuous intravenous SSA (0.3 mg/8 h) for 3 days from POD1, and the latter normal saline. The primary outcome was the incidence of POPF. Results: The incidence of POPFs in the SSA group was significantly lower than that in the control group (3.3% vs. 14.5%, P = 0.029). The incidence of short-term postoperative complications was significantly lower in the SSA group than in the control group (9.8% vs. 24.2%, P = 0.034). The median white blood cell counts, neutrophil counts, and the percentage of neutrophils on POD4 were significantly lower in the SSA group than in the control group (all P < 0.05). The SSA group had a shorter mean time to the first liquid diet (87.33 ± 17.92 h vs. 93.97 ± 17.29 h, P = 0.039). And the SSA group had less median daily drainage volume (96.33 mL vs. 119.67 mL, P = 0.025) and shorter drainage duration (7.0 days vs. 10.0 days, P = 0.013). Conclusion: Postoperative treatment with a somatostatin analog reduced the incidence of POPF and short-term complications after radical gastrectomy. (TRN: ChiCTR2200056201, Reg. Date: 2022/2/1).
- Subjects
GASTRECTOMY; PANCREATIC fistula; SURGICAL complications; LYMPHADENECTOMY; LEUKOCYTE count
- Publication
Journal of Cancer Research & Clinical Oncology, 2023, Vol 149, Issue 9, p6329
- ISSN
0171-5216
- Publication type
Article
- DOI
10.1007/s00432-023-04584-7