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- Title
The genetics of gene expression in complex mouse crosses as a tool to study the molecular underpinnings of behavior traits.
- Authors
Hitzemann, Robert; Bottomly, Daniel; Iancu, Ovidiu; Buck, Kari; Wilmot, Beth; Mooney, Michael; Searles, Robert; Zheng, Christina; Belknap, John; Crabbe, John; McWeeney, Shannon
- Abstract
Complex Mus musculus crosses provide increased resolution to examine the relationships between gene expression and behavior. While the advantages are clear, there are numerous analytical and technological concerns that arise from the increased genetic complexity that must be considered. Each of these issues is discussed, providing an initial framework for complex cross study design and planning.
- Subjects
GENE expression in mammals; MOLECULAR genetics; MICE behavior; MICE genetics; MAMMAL genomes
- Publication
Mammalian Genome, 2014, Vol 25, Issue 1/2, p12
- ISSN
0938-8990
- Publication type
Article
- DOI
10.1007/s00335-013-9495-6