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- Title
Interaction of morphine but not fentanyl with cerebral α2-adrenoceptors in α2-adrenoceptor knockout mice.
- Authors
Jan Höcker; Ruwen Böhm; Patrick Meybohm; Matthias Gruenewald; Jochen Renner; Henning Ohnesorge; Jens Scholz; Berthold Bein
- Abstract
The article focuses on a study which aims to evaluate the direct functional interactions between μ-opioid and α2-adregenic receptors. It says that quantitative receptor autoradiography was used in investigating the opioid interaction with α2-adrenoceptors in the brain slices of mice. Results show that the morphine provoked the dose-dependent displacement of paraiodoclonidine in the regions of brain.
- Subjects
ALPHA adrenoceptors; OPIOID receptors; BRAIN physiology; LABORATORY mice; FUNCTIONAL renormalization group (Statistical physics)
- Publication
Journal of Pharmacy & Pharmacology, 2009, Vol 61, Issue 7, p901
- ISSN
0022-3573
- Publication type
Article
- DOI
10.1211/jpp.61.07.0009