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- Title
Protective effects of baicalin magnesium on non-alcoholic steatohepatitis rats are based on inhibiting NLRP3/Caspase-1/IL-1β signaling pathway.
- Authors
Guan, Xiulu; Shen, Shiyuan; Liu, Jinxia; Song, Hongru; Chang, Jinhua; Mao, Xiaoxia; Song, Jingyu; Zhang, Lin; Liu, Cuizhe
- Abstract
Baicalin magnesium is a water-soluble compound isolated from the aqueous solution by Scutellaria baicalensis Georgi. Preliminary experiments have demonstrated that baicalin magnesium can exert protective effects against acute liver injury in rats induced by carbon tetrachloride or lipopolysaccharide combined with d-galactose by regulating lipid peroxidation and oxidative stress. The aim of this study was to investigate the protective effect of baicalin magnesium on non-alcoholic steatohepatitis (NASH) in rats and to elucidate the underlying mechanisms. NASH was induced through a high-fat diet (HFD) for 8 weeks, and Sprague-Dawley rats were intravenously injected with baicalin magnesium, baicalin, and magnesium sulfate for 2 weeks, respectively. Serum was obtained for biochemical analyses and the determination of oxidative stress indicators. Liver tissues were collected for use in liver index assessment, histopathological examination, inflammatory factor analysis, and protein and gene expression analysis. The results revealed that baicalin magnesium markedly improved HFD-induced lipid deposition, inflammatory response, oxidative stress, and histopathological impairments. And baicalin magnesium may exert a protective effect on NASH rats by inhibiting the NLR family pyrin domain involving the 3 (NLRP3)/caspase-1/interleukin (IL)-1β inflammatory pathway. Additionally, the effect of baicalin magnesium was remarkably superior to that of equimolar baicalin and magnesium sulfate in regard to ameliorating NASH symptoms. In conclusion, the findings suggested that baicalin magnesium may represent a potential drug for the treatment of NASH.
- Subjects
INTERLEUKINS; BIOMARKERS; MAGNESIUM sulfate; CYTOKINES; REVERSE transcriptase polymerase chain reaction; STAINS &; staining (Microscopy); ANIMAL experimentation; SERUM; INFLAMMATION; WESTERN immunoblotting; ONE-way analysis of variance; NON-alcoholic fatty liver disease; SUPEROXIDE dismutase; PHYTOCHEMICALS; CELLULAR signal transduction; RATS; OXIDATIVE stress; GENE expression; MALONDIALDEHYDE; MAGNESIUM; RESEARCH funding; PLANT extracts; MOLECULAR structure; DATA analysis software; CASPASES; LIPIDS
- Publication
BMC Complementary Medicine & Therapies, 2023, Vol 23, Issue 1, p1
- ISSN
2662-7671
- Publication type
Article
- DOI
10.1186/s12906-023-03903-2