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- Title
Biochemistry: Designer label.
- Abstract
The article reports on the study of Carolyn Bertozzi and colleagues on chemical labelling of molecules without causing toxicity to animal subjects at the University of California, Berkeley. It notes that molecular labelling in living animals can provide insight regarding metabolism and disease process. It mentions that Bertozzi's team injected the mice with nitrogen-based chemical azide which is bound to sialic acids found on cell surfaces. It cites that the team introduced another cyclooctyne compound which was linked to the fluorescent probe. Moreover, Bertozzi's chemical technique does not rely on copper catalyst.
- Subjects
BERKELEY (Calif.); CALIFORNIA; BIOCHEMISTRY; MOLECULES; METABOLISM; AZIDES; SIALIC acids; COPPER catalysts; BERTOZZI, Carolyn, 1966-; UNIVERSITY of California, Berkeley
- Publication
Nature, 2010, Vol 463, Issue 7279, p272
- ISSN
0028-0836
- Publication type
Article
- DOI
10.1038/463272f