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- Title
EGF–ERBB signalling: towards the systems level.
- Authors
Citri, Ami; Yarden, Yosef
- Abstract
Signalling through the ERBB/HER receptors is intricately involved in human cancer and already serves as a target for several cancer drugs. Because of its inherent complexity, it is useful to envision ERBB signalling as a bow-tie-configured, evolvable network, which shares modularity, redundancy and control circuits with robust biological and engineered systems. Because network fragility is an inevitable trade-off of robustness, systems-level understanding is expected to generate therapeutic opportunities to intercept aberrant network activation.
- Subjects
CANCER; ANTINEOPLASTIC agents; THERAPEUTICS; CANCER treatment; CELL receptors
- Publication
Nature Reviews Molecular Cell Biology, 2006, Vol 7, Issue 7, p505
- ISSN
1471-0072
- Publication type
Article
- DOI
10.1038/nrm1962