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- Title
Early nonsense: mRNA decay solves a translational problem.
- Authors
Amrani, Nadia; Sachs, Matthew S.; Jacobson, Allan
- Abstract
Gene expression is highly accurate and rarely generates defective proteins. Several mechanisms ensure this fidelity, including specialized surveillance pathways that rid the cell of mRNAs that are incompletely processed or that lack complete open reading frames. One such mechanism, nonsense-mediated mRNA decay, is triggered when ribosomes encounter a premature translation-termination — or nonsense — codon. New evidence indicates that the specialized factors that are recruited for this process not only promote rapid mRNA degradation, but are also required to resolvea poorly dissociable termination complex.
- Subjects
GENE expression; MESSENGER RNA; RIBOSOMES; ORGANELLES; PROTEINS
- Publication
Nature Reviews Molecular Cell Biology, 2006, Vol 7, Issue 6, p415
- ISSN
1471-0072
- Publication type
Article
- DOI
10.1038/nrm1942