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- Title
IS INTRACYTOPLASMIC MORPHOLOGICALLY SELECTED SPERM INJECTION (IMSI) DETRIMENTAL FOR PREGNANCY OUTCOME?
- Authors
Junca, A. M.; Dumont, M.; Belloc, S.; Olivennes, F.; Aubriot, F. X.; Cohen-Bacrie, P.; Prisant, N.
- Abstract
Objective: Since the advent of high magnification sperm selection (x6600), IMSI allows for pregnancies in cases where failure can be related to the injection of abnormal sperm undetected in ICSI. As for any new technique, it was necessary to prove that it is safe for the resulting pregnancies and for the babies. As IMSI has been practiced in our lab since 2004, pregnancy data may be analyzed on a large number of cases. Design: Retrospective analysis of a prospective cohort. Materials and Methods: From 2004 to 2008, 2097 IMSI were done in our lab (19.3% of all ICSI), with a clinical pregnancy rate of 23%/oocyte retrieval. Data could be assessed for 458 of the 482 pregnancies (95%). Pregnancy outcome and neonatal data were compared to those of all conventional ICSI pregnancies during the same period of time (n = 1841), globally and taking into account semen parameters (oligozoospermia for a concentration <20 millions/mL and teratozoospermia if the percentage of normal forms was <10% by David's standards). Statistical analysis included multivariate models. Results: Table 1 shows the overall results for the 2 groups. There was no difference between IMSI and ICSI pregnancy outcome and neonatal data, except for the percentage of babies weighing less than 2500 g. Those results were not modified when taking semen parameters into account. Conclusions: In term of pregnancy outcome, IMSI appeared as safe as ICSI. However, the difference in birth weight needs to be explored, and the results on perinatal death and on congenital abnormalities need to be confirmed on larger numbers.
- Subjects
SPERMATOZOA; PREGNANCY; INFANTS; HUMAN abnormalities; MORPHOLOGY
- Publication
Reproductive BioMedicine Online (Reproductive Healthcare Limited), 2010, Vol 20, pS29
- ISSN
1472-6483
- Publication type
Article
- DOI
10.1016/S1472-6483(10)62490-X