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- Title
Serum concentrations of selected adipokines in virusrelated liver cirrhosis and hepatocellular carcinoma.
- Authors
Pazgan-Simon, Monika; Zuwała-Jagiełło, Jolanta; Kukla, Michał; Grzebyk, Ewa; Simon, Krzysztof
- Abstract
Aim of the study: Hepatotropic viruses cause metabolic disturbances such as insulin resistance and hepatosteatosis. Moreover, metabolic factors, such as insulin resistance, obesity, and type 2 diabetes mellitus, increase the risk for hepatocellular carcinoma (HCC) in patients with virus-related liver cirrhosis. Cytokines secreted by the adipose tissue (adipokines) may be implicated in these metabolic disturbances, but there is little evidence regarding the role of adipokines in virus-related cirrhosis and HCC. Thus, we studied whether serum concentrations of selected adipokines were altered in patients with virus-related liver cirrhosis, including patients with HCC. Material and methods: We included 43 patients with liver cirrhosis due to chronic hepatitis B or chronic hepatitis C. Of these patients, 36 had HCC and 7 did not have any malignant lesions. In addition to routine clinical and laboratory variables, we analyzed serum concentrations of betatrophin, insulin, vaspin, visfatin, and irisin. Results: Compared with healthy controls, patients with HCC had significantly increased vaspin concentrations and significantly reduced irisin concentrations. Compared with controls, patients with virus-related cirrhosis, with or without HCC, had significantly increased concentrations of insulin and betatrophin. The serum visfatin concentration was non-significantly higher in patients with virus-related cirrhosis than in controls. None of the studied adipokines was a significant predictor of HCC. Serum concentrations of the studied adipokines were not related to cirrhosis severity or HCC stage. Conclusions: Metabolic parameters, including serum adipokine concentrations, are altered in patients with virus-related liver cirrhosis. Adipokines might be related to the HCC risk in these patients.
- Subjects
ADIPOKINES; CIRRHOSIS of the liver; HEPATOCELLULAR carcinoma; INSULIN resistance; TYPE 2 diabetes
- Publication
Clinical & Experimental Hepatology, 2020, Vol 6, Issue 3, p235
- ISSN
2392-1099
- Publication type
Article
- DOI
10.5114/ceh.2020.99517