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- Title
Shaping and reshaping CD8<sup>+</sup> T-cell memory.
- Authors
Harty, John T.; Badovinac, Vladimir P.
- Abstract
The ability to develop and sustain populations of memory T cells after infection or immunization is a hallmark of the adaptive immune response and a basis for protective vaccination against infectious disease. Technical advances that allow direct ex vivo identification and characterization of antigen-specific CD8+ T cells at various stages of the response to infection or vaccination in mouse models have fuelled efforts to characterize the factors that control memory CD8+ T-cell generation. Here, we dissect the input signals that shape the characteristics of the memory CD8+ T-cell response and discuss how manipulation of these signals has the potential to reshape CD8+ T-cell memory and improve the efficacy of vaccination.
- Subjects
T cells; CELLS; IMMUNE response; IMMUNIZATION; VACCINATION; ANTIGENS
- Publication
Nature Reviews Immunology, 2008, Vol 8, Issue 2, p107
- ISSN
1474-1733
- Publication type
Article
- DOI
10.1038/nri2251