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- Title
Antigens and immunoevasins: opponents in cytomegalovirus immune surveillance.
- Authors
Reddehase, Matthias J.
- Abstract
CD8+ T cells are the main effector cells for the immune control of cytomegaloviruses. To subvert this control, human and mouse cytomegaloviruses each encode a set of immune-evasion proteins, referred to here as immunoevasins, which interfere specifically with the MHC class I pathway of antigen processing and presentation. Although the concerted action of immunoevasins prevents the presentation of certain viral peptides, other viral peptides escape this blockade conditionally or constitutively and thereby provide the molecular basis of immune surveillance by CD8+ T cells. The definition of viral antigenic peptides that are presented despite the presence of immunoevasins adds a further dimension to the prediction of protective epitopes for use in vaccines.
- Subjects
T cells; CELLULAR immunity; CYTOMEGALOVIRUS diseases; ANIMAL experimentation; COMPARATIVE studies; CYTOMEGALOVIRUSES; HISTOCOMPATIBILITY antigens; RESEARCH methodology; MEDICAL cooperation; MICE; PROTEINS; RESEARCH; VIRAL antigens; DISEASE relapse; VIRAL physiology; EVALUATION research
- Publication
Nature Reviews Immunology, 2002, Vol 2, Issue 11, p831
- ISSN
1474-1733
- Publication type
research
- DOI
10.1038/nri932