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- Title
OPINION: From T to B and back again: positive feedback in systemic autoimmune disease.
- Authors
Shlomchik, Mark J.; Craft, Joseph E.; Mamula, Mark J.
- Abstract
Systemic lupus erythematosus, a prototypical systemic autoimmune disease, is the result of a series of interactions within the immune system that ultimately lead to the loss of self-tolerance to nuclear autoantigens. Here, we present an integrated model that explains how self-tolerance is initially lost and how the loss of tolerance is then amplified and maintained as a chronic autoimmune state. Key to this model are the self-reinforcing interactions of T and B cells, which we suggest lead to perpetuation of autoimmunity as well as its spread to multiple autoantigen targets.
- Subjects
LUPUS erythematosus; AUTOIMMUNE diseases; AUTOIMMUNITY; T cells; B cells
- Publication
Nature Reviews Immunology, 2001, Vol 1, Issue 2, p147
- ISSN
1474-1733
- Publication type
Article
- DOI
10.1038/35100573