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- Title
Association Between ER And HER2neu Status with Various Sonographic Findings in Breast Cancer.
- Authors
Hasan, Farah Falah; Hashim, Ali Fadhil; Fadhil, Mohammed Haider
- Abstract
Introduction: Diagnostic ultrasonography is used as a radiological modality for assessing clinically suspected mammary lesions based on certain radiological criteria. Objectives: This study was conducted to investigate the association between ultrasound based radiological findings and biological markers (estrogen receptor ER and HER2\NEU) in invasive mammary carcinoma. Materials and methods: In this study 100 samples were collected retrospectively; each sample consist of one Hematoxylin and Eosin (H&E) stained histological section of invasive mammary carcinoma diagnosed by core needle biopsy together with the relevant immunohistochemical sections for ER and Her2Neu. The histological and immunohistochemical sections were carefully reviewed by two independent pathologists for assigning appropriate grading by using Nottingham modification of Bloom-Richardson system and an appropriate immunohistochemical scoring. For each sample, patient age, cytological report and the relevant sonographic data were extracted from the patient clinical request forms in the archive of data. The results were statically correlated by using chi square test. Results: The study enrolled 100 histological sample of invasive mammary carcinoma diagnosed by core needle biopsy, 52% from the right breast and 48 % from the left one, age range of patient was from 28 to 80 years with a mean age of 53 years. 64 % were estrogen receptor positive, 54% were HER2\NEU positive. There was a significant statistical correlation between ER and HER2\NEU positivity with the ultrasonic features of positive axillary lymph node metastasis. While a non-statistical relationship was achieved between ER and HER2\NEU positivity with various sonographic findings in invasive mammary carcinoma. Conclusion: Ultrasound based findings of a primary malignant breast mass are of no help to predict ER and HER2 status of invasive mammary carcinoma.
- Subjects
NOTTINGHAM (England); CORE needle biopsy; DIAGNOSTIC ultrasonic imaging; BREAST cancer; CHI-squared test; STATISTICAL correlation; LOBULAR carcinoma
- Publication
Kerbala Jorunal of Medicine, 2023, Vol 16, Issue 2, p2662
- ISSN
1990-5483
- Publication type
Article