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- Title
Microglia in drug addiction: A perspective from neuroimmunopharmacology.
- Authors
Cong Lin; Xiaohui Wang
- Abstract
This article discusses the role of microglia, immune cells in the central nervous system, in drug addiction. Microglia are activated when exposed to drugs and release inflammatory mediators that can lead to neuronal toxicity and synaptic dysfunction. Chronic drug abuse can also induce microglial priming, resulting in persistent neuroinflammation. The article explores potential therapeutic approaches for mitigating drug addiction by targeting microglia, such as inhibiting specific receptors and signaling pathways or depleting microglia. The concept of microglial replacement as a strategy for restoring normal microglial function is also discussed. The article emphasizes the need for further research in this area and the potential for personalized treatment strategies.
- Subjects
DRUG addiction; MICROGLIA; TREATMENT of drug addiction; MACROPHAGE colony-stimulating factor; ALCOHOLISM; ALKALOIDS; OPIOID receptors; DOPAMINE receptors; NALOXONE
- Publication
Zoological Research, 2024, Vol 45, Issue 3, p704
- ISSN
2095-8137
- Publication type
Article
- DOI
10.24272/j.issn.2095-8137.2023.286