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- Title
Coenzyme Q<sub>10</sub> Protects From Aging-Related Oxidative Stress and Improves Mitochondrial Function in Heart of Rats Fed a Polyunsaturated Fatty Acid (PUFA)-Rich Diet.
- Authors
Ochoa, Julio J.; Quiles, José L.; Huertas, Jesús R.; Mataix, José
- Abstract
Coenzyme Q10 supplementation on age-related changes in oxidative stress and function of heart mitochondria in rats fed a polyunsaturated fatty acid (PUFA)-rich diet was investigated. Two groups of rats were fed for 24 months on a PUFA-rich diet, differing in supplementation or not with coenzyme Q10. Animals were killed at 6, 12, or 24 months. Fatty-acid profile, hydroperoxides, α-tocopherol, coenzyme Q, catalase and glutathione peroxidase activities, and cytochromes a+a3, b, c+c1 and cytochrome c oxidase activity were measured. Coenzyme Q10-supplemented animals showed lower hydroperoxide levels; higher content and/or activity of α-tocopherol, coenzyme Q, and catalase; and a slightly lower decrease in mitochondrial function. According to that, previously reported positive effects of coenzyme Q supplementation on the life span of rats fed a PUFA-rich diet might be a consequence, at least in part, of a lower oxidative stress level and perhaps, to a minor extent, of a smaller decrease in mitochondrial function.
- Subjects
COENZYMES; MITOCHONDRIA; GLUTATHIONE; OLIGOPEPTIDES; CYTOCHROMES
- Publication
Journals of Gerontology Series A: Biological Sciences & Medical Sciences, 2005, Vol 60, Issue 8, p970
- ISSN
1079-5006
- Publication type
Article
- DOI
10.1093/gerona/60.8.970