We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
The increase of neuropathic symptoms in diabetic patients is related with osteopenia.
- Authors
Börekci, Elif; Kara, Adem; Kılıç, Mahmut; Tanık, Nermin; Ozan, Zeynep T.; Yıldırım, Tekin; Aral, Yalçın
- Abstract
Purpose: To investigate the relationship between the intensity of neuropathic pain and the severity of osteopenia in type 2 diabetic patients with painful diabetic peripheral neuropathy (painful DPN). Methods: In 220 patients with type 2 diabetes included in the screening, the presence of neuropathic pain was evaluated using the Douleur Neuropathique 4 Questions (DN4) scoring system. One hundred forty-five patients with painful DPN were identified and included in the study. Socio-demographic and laboratory evaluations were made and bone mineral density (BMD) of these patients was evaluated by the dual-energy x-ray absorptiometry (DEXA) method. Results: There was a significant correlation between the neuropathic pain score and the total T scores of the lumbar spine and femur in patients with painful DPN. According to the regression analysis (standard coefficients), the DN4 score (0.498); the level of vitamin D (− 0.246) and the female sex (0.236) for the lumbar spine region; age (0.387); DN4 score (0.261); and vitamin D level (− 0.155) for the femur region were independently influencing factors on the development of osteoporosis. When osteoporosis (T score ≤ − 2.5) of the lumbar spine was analyzed by binary logistic regression, the risk of osteoporosis in women was 4.4 times higher, and the risk increased with increasing DN4 score. Conclusion: The increase of neuropathic symptoms in patients with DPN is an effective and important factor in the development of diabetic osteopenia.
- Subjects
SYMPTOMS; PEOPLE with diabetes; BONE density; NEURALGIA; OSTEOPENIA; OSTEOPOROSIS; TYPE 2 diabetes
- Publication
Neurological Sciences, 2021, Vol 42, Issue 7, p2873
- ISSN
1590-1874
- Publication type
Article
- DOI
10.1007/s10072-020-04915-3