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- Title
Serotonin syndrome due to concomitant use of linezolid and methadone.
- Authors
Masbough, Farnoosh; Roshanzamiri, Soheil; Rahimi, Mitra; Sahraei, Zahra; Evini, Peyman Erfan Talab
- Abstract
Serotonin syndrome is a potentially life‐threatening adverse drug reaction typically caused by a single or combination of two or more medications with serotonergic properties due to increased serotonin release. Our case is a 60‐year‐old drug‐addict man who was admitted to the poisoning department of Loghman hospital with methadone poisoning. On the fifth day of hospitalization and after initiating the linezolid treatment for VAP, the patient began to run a fever with agitation, tremor, spontaneous clonus movement in the hands, and tachycardia. Due to patients' manifestations and after ruling out other diagnoses, serotonin syndrome was confirmed with the possibility of concomitant use of linezolid and methadone. Linezolid administration was promptly discontinued, and vancomycin therapy was initiated (1000 mg twice a day intravenously). Supportive therapies were performed. Finally, tremor, rigidity, and clonus movement disappeared within 48 h. Before starting any new medication, any medications the patient are already taking should be investigated for interactions. Serotonin syndrome can be life‐threatening and could have been avoided if this had been done.
- Subjects
SEROTONIN syndrome; DRUG side effects; LINEZOLID; METHADONE hydrochloride
- Publication
Clinical Case Reports, 2022, Vol 10, Issue 11, p1
- ISSN
2050-0904
- Publication type
Case Study
- DOI
10.1002/ccr3.6341