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- Title
FUNGICIDAL ACTIVITY AND CHEMICAL CONSTITUTION.
- Authors
BYRDE, R. J. W.; CLIFFORD, D. R.; WOODCOCK, D.
- Abstract
A series of 5- n-alkyl oxines was tested against the mycelium of Aspergillus niger. As non-chelated molecules, they showed maximum fungistatic activity at a chain length of 5-6 carbon atoms. Values of Ferguson's thermodynamic activity coefficient, obtained from spore germination tests with Sclerotinia laxa, indicated that the mechanism of toxicity of the lower homologues is predominantly chemical, whilst that of the n-amyl and higher members is mainly physical. The ED 50 value of 5- n-amyl-6-hydroxyquinoline, which is incapable of chelation, was found to be eighty times greater than that of 5- n-amyl oxine (in the non-chelated form). The optimum initial pH for fungistatic activity of the latter was 5.4-5.6. In the presence of metals the pattern of fungistatic activity was markedly altered: maximum activity in the presence of Cu2+, Fe2+and Zn2+was found with oxine and 5-methyloxine.
- Publication
Annals of Applied Biology, 1958, Vol 46, Issue 2, p167
- ISSN
0003-4746
- Publication type
Article
- DOI
10.1111/j.1744-7348.1958.tb02193.x