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- Title
Nuclear Magnetic Resonance-based Metabolomics in Patients with Rheumatoid Arthritis.
- Authors
ÇELİKEL, Rıdvan; SELEK, Şahabettin
- Abstract
Introduction: Rheumatoid arthritis (RA); is an inflammatory autoimmune disease that is common in the population and is characterized by painful and swollen joints that seriously affect physical function and quality of life. Patients with RA are much more prone to serious infections, respiratory distress, and cardiovascular disease than the normal population. In the diagnosis of RA, with the clinic of the patients, X-ray and ultrasound images and laboratory results of the patients help diagnos; however, further investigations are still needed since RA is thought to be a genetically based disease. Nuclear magnetic resonance (NMR) has being used for years to diagnose different amounts of diseases, including rheumatologic diseases. NMR is the best option to image the body metabolism, which is crucial to understand better the autoimmune diseases such as RA. Method: For this study, 2 different groups were determined. For the patient group, 120 urine samples were taken from patients with RA. For the control group, 120 urine samples were taken from healthy people. These samples were studied in an NMR device and the results were compared through liquid chromatography-mass spectrometer (MS)/MS device. Results: After examining urine samples through an NMR device, 7 metabolites's p values were found different. P values of threonine, histidine, N-Acetylglutamine, and lactate were higher in the patient group, in contrast; p values of acetate, methylmalonate, and asparagine were lower in the patient group compared the control group. Besides p values, correlations were detected between 20 different metabolites, which were studied in urine samples of both groups Conclusion: It is clear that there are some metabolical differences between the urine of an patient with RA and a healthy person. To diagnose and treat RA, these differences may be assessed.
- Subjects
RHEUMATOID arthritis; JOINT pain; NUCLEAR magnetic resonance; MASS spectrometers; METABOLOMICS; BODY image; AUTOIMMUNE diseases
- Publication
Bezmialem Science, 2023, Vol 11, pS3
- ISSN
2148-2373
- Publication type
Article