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- Title
Cardiac Resynchronization Therapy and the Arrhythmogenic Substrate.
- Authors
LUX, ROBERT L.; HAMDAN, MOHAMED H.
- Abstract
The article focuses on cardiac resynchronization therapy and the arrhythmogenic substrate. Cardiac resynchronization therapy (CRT) is rapidly evolving as a viable treatment for patients suffering from congestive heart failure, cardiomyopathy, or other cardiac diseases in which hemodynamic performance has been impaired. A fundamental precept of cardiac electrophysiology is that altering the activation sequence alters the repolarization sequence and the repolarization heterogeneity. Since repolarization heterogeneity is an established and significant factor in reentrant arrhythmias, any pacing strategy that alters the normal depolarization sequence has the potential to alter the arrhythmogenic substrate either in a favorable or unfavorable manner.
- Subjects
CARDIAC arrest; THERAPEUTICS; HEART failure; DISEASE complications; HEART beat; HEART diseases
- Publication
Journal of Cardiovascular Electrophysiology, 2005, Vol 16, Issue 6, p618
- ISSN
1045-3873
- Publication type
Editorial
- DOI
10.1111/j.1540-8167.2005.50031.x